PREPARATION VETOM 1.23 ACTIVITY AGAINST BHV-1 UNDER CONDITIONS IN VITRO
Abstract
The search for new preparations effective against viral causative agents in cattle infections is the most important objective of the modern veterinary pharmachology. The virus of infectious bovine rhinotracheitis is widespread on the farms of Siberian region and plays an important part in animal pathology causing big economic losses in the modern livestock-breeding. Antiviral activity of the preparations referred to the group of probiotics is little studied. The antiviral activity of vetom 1.23 against BHV-1 is determined in vitro. The antiviral activity was assessed by reduction of the virus; the assessment was conducted after the virus’s having interacted with vetom 1.23. Graft cell culture of MDBK calf’s kidney was used in the experiment. Avirulent strain ТК-А was used as the virus-test. vetom 1.23 was introduced in the maximal tolerant concentration (62.5 mm3 / cm3 ). The experimental outcomes showed that vetom 1.23 at the dose recommended for the examination and introduced (maximal tolerant concentration) appeared to be little effective against BHV-1, it was poor inhibition in virus multiplication that was observed; the virus titer went down by 0.13–0.5 log10. However, the preparation manifested expressed antivirus effect in higher concentrations.
About the Authors
T. I. Glotova
Институт экспериментальной ветеринарии Сибири и Дальнего Востока Россельхозакадемии
Russian Federation
Russian Federation
A. G. Glotov
Институт экспериментальной ветеринарии Сибири и Дальнего Востока Россельхозакадемии
Russian Federation
Russian Federation
G. A. Nozdrin
Новосибирский государственный аграрный университет
Russian Federation
Russian Federation
A. A. Nikonova
Новосибирский государственный аграрный университет
Russian Federation
Russian Federation
O. V. Semenova
Институт экспериментальной ветеринарии Сибири и Дальнего Востока Россельхозакадемии
Russian Federation
Russian Federation
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Review
For citations:
Glotova T.I., Glotov A.G., Nozdrin G.A., Nikonova A.A., Semenova O.V. PREPARATION VETOM 1.23 ACTIVITY AGAINST BHV-1 UNDER CONDITIONS IN VITRO. Bulletin of NSAU (Novosibirsk State Agrarian University). 2014;(3):85-90. (In Russ.)
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