REGULATIONS OF STRUCTURAL-FUNCTIONAL CHANGES IN RAT BRAIN CAUSED BY PATHOGENIC EFFECTS OF ENVIRONMENT

Abstract

General regulation of structural-functional changes in brain structures is shown when exposed to anthropogenic stress. By the 14-21st experimental day the dramatic decrease in the total numerical density of neurons is observed, on the 30-45th day of the experiment the numerical density of neurons partially recovers at the expense of the compensatory mechanism of developing adaptation syndrome, since the 45-60th day there is a repeated decrease in the total numerical density of neurons and the transition of adaptation syndrome to decompensation stage, on the 60th-90th day the acute process becomes chronic and the total numerical density of neurons decreases. Rearrangement characteristic is selectivity in damaging hippocamp. Degenerative changes take place in all the sectors, there being the maximal numerical density of irreversibly altered, shriveled, focally missed out, hyperchromatic neurons in CA3 sector and the developed pace-maker dominant zone of generalized excitation in CA1 sector of the experimental animals’ hippocamp. The complex methodical approach employed allowed to obtain a complete quantitative and qualitative characteristic of neurons and interneuron synapses, that of brain limbic structures examined and hippocamp sectors.