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ACUTE AND CHRONICAL TOXICITY OF THE SPECIMEN BASED ON ESSENTIAL OIL OF SIBERIAN FIR (ABIES SIBIRICA)

Abstract

The authors conducted toxicological and allergic research and explored new specimen Aerosan-P which is based on essential oil of Siberian fir (Abies sibirica L.). The specimen is used for prevention and treatment of respiratory diseases. The research found out that the specimen was safe for laboratory animals and young cattle. The researchers explored acute toxicity on white rats and white mice when they applied the specimen to rats and mice dozed 3000 and 5000 mg/kg. Epidermal acute toxicity of Aerosan-P was investigated on the white rats by means of its epidermal application in 2 variants: 2500 mg/kg (0.5 gpro a rat) and 5000 mg/kg (1 gpro a rat). The data of percutaneous and peroral toxicity received shows that according to the GOST 12.1.007–76. Hazardous substances. Classification and general requirements of safety, the specimen is referred to the 4th hazard category – low-hazard substances. The researchers explored the impact of the specimen on mucous membranes and potential irritation effect when they applied 5 mg of the specimen on the left eye cornea of rabbits whereas the right eye was controlled. The specimen doesn’t have an impact on the rats’ skin and rabbits’ eyes. The authors explored the chronic toxicity of the specimen on the young Black-and-White cattle and applied 1500 and 750 mg/kg of the specimen during 30 days. The animals were controlled during the whole period of experiment. The authors found out that the specimen didn’t influence negatively the young cattle health.

About the Authors

A. V. Liakhova
Novosibirsk State Agrarian University
Russian Federation
PhD-student


N. N. Gorb
Novosibirsk State Agrarian University
Russian Federation
Candidate of Veterinary Sc.


Iu. G. Popov
Novosibirsk State Agrarian University
Russian Federation
Doctor of Veterinary Sc.


M. N. Skomarova
Rosvetfarm
Russian Federation
Candidate of Veterinary Sc.


L. V. Makarenko
Rosvetfarm
Russian Federation
Veterinary doctor


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For citations:


Liakhova A.V., Gorb N.N., Popov I.G., Skomarova M.N., Makarenko L.V. ACUTE AND CHRONICAL TOXICITY OF THE SPECIMEN BASED ON ESSENTIAL OIL OF SIBERIAN FIR (ABIES SIBIRICA). Bulletin of NSAU (Novosibirsk State Agrarian University). 2016;(4):97-103. (In Russ.)

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ISSN 2072-6724 (Print)