THE ANALYSIS OF CHEMATHERAPEUTIC AGENTS APPLIED IN DAIRY ANIMAL BREEDING OF RUSSIA
Abstract
The paper analyzes the range of antimicrobial agents endorsed for application in dairy cattle breeding ofRussia. The analysis is based on the indicators of total drugs for cows and active agents in the combined medical drugs. The authors analyzed the combinations of medical agents in drugs. The research found out that antibacterial specimens recommended for treatment cows diseases make 9.2% of total drugs and feeding additives for animals, which are included into the list. The combined drugs make 22.8%; specimens containing tetracycline – 17%; fluroquinolone – 13.8%; penicillin – 13.4%; cephalosporin – 10.7%, aminoglycoside – 7.1, macrolide – 6.7, chloramphenicol and florfenicol4.9%; sulfanilamide – 1.8%, metronidazole and oxyquinoline products – 0.4% each agent. The analysis of combined drugs for treatment of cow mastitis shows the highest concentration of penicillin (75%), aminoglycoside (65%), tetracycline (20%), cephalosporin and quinoxaline products (15%), lincosamides (10%), macrolides and sulfanilamides (5%). Veterinary pharmaceutical market registers polycomponent drugs (4 and more medical agents in a drug) that require special reasons for application. The following antibiotics contained in milk are controlled: chloramphenicol, tetracycline, penicillin and streptomycin. This doesn’t mean that the remnants of antibacterial drugs can accumulate in dairy products: quinoxaline products and quinolones, cephalosporin, metronidazole, florfenicol, lincosamides, macrolides and aminoglycosides of new generation.
About the Authors
T. V. BoikoRussian Federation
Doctor of Veterinary Sc., Associate Professor
L. K. Gerunova
Russian Federation
Doctor of Veterinary Sc., Professor
References
1. Tekhnicheskiy reglament Tamozhennogo soyuza (TR TS – 033–2013) [Technical Regulations of the Customs Union]: http://www.gost.ru/.
2. Gosudarstvennyy reestr lekarstvennykh sredstv dlya veterinarnogo primeneniya [State Register of medicinal products for veterinary use]: https://irena.vetrf.ru/irena/operatorui?_action=clearRegListMedicine.
3. Gerunova L.K., Red’kin Yu.V. Veterinarnyy konsul’tant, no. 4 (2007): 12–14. (In Russ.)
4. Lourens D.P., Benitt P.N. Klinicheskaya farmakologiya [Clinical pharmacology]. Moscow: Meditsina, T. 1 (1991): 265. (In Russ.)
5. Postnikov S.S. Prakticheskaya pul’monologiya, no. 2 (2006): 43–47: https://cyberleninka.ru/article/n/toksicheskoe-deystvie-antibiotikov. (In Russ.)
6. Sachek M.M., Bizunkov A.B., Kurlyuk O.V. Meditsinskie novosti, no. 1 (2011): 21–25: https://cyberleninka.ru/article/n/sovremennye-podhody-k-ogranicheniyu-ototoksichnosti-aminoglikozidov. (In Russ.)
7. Cherkashina N.V., Drozdova L.I., Makhortov V.L. i dr. Agrarnyy vestnik Urala, no. 3 (2011): 39– 42. (In Russ.)
8. Mastileks. Instruktsiya po primeneniyu preparata [Instructions for use of the drug Mastileks]: http://www.vidal.ru/veterinar/mastilex-27938. (In Russ.)
9. Mikhaylov I.B. Klinicheskaya farmakologiya [Clinical pharmacology]. Moscow: Meditsina, 1998. pp. 59: http://padaread.com/?book=17642.
10. Mul’tidzhekt IMM® Instruktsiya po primeneniyu preparata [Instructions for use of the drug Mul’tidzhekt IMM®]: http://agrosfera55.ru/catalog/kategoriya-9/multidzhek.html.
11. Shabunin S.V., Vostroilova G.A. Sovremennye problemy veterinarnogo obespecheniya reproduktivnogo zdorov’ya zhivotnykh [Conference proceedings].Voronezh: Istoki, 2009. pp. 13–17. (In Russ.)
12. FDA (2011) Summary Report On Antimicrobials Sold or Distributed for Use in Food-Producing Animals. Department of Health and Human Services: http://www.fda.gov/downloads/ForIndustry/UserFees/AnimalDrugUserFeeActADUFA/UCM338170.pdf.
13. Sarmah A.K., Meyer M.T., Boxall A. A global perspective on the use, sales, exposure pathways, occurrence, fate and effects of veterinary antibiotics (VAs) in the environment. Chemosphere, 65 (2006): 725–759: http://www.ncbi.nlm.nih.gov/pubmed/16677683.
14. Hornish R.E., Katarski S. Cephalosporins in veterinary medicine-ceftiofur use in food animals. Curr Top Med Chem, 2 (2002): 717–731: http://www.ncbi.nlm.nih.gov/pubmed/12052187.
15. Shkil» N.N. Vestnik NGAU [Bulletin of NSAU], no. 3 (36) (2015): 107–115.
16. Wichmann F., Udikovic-Kolic N., Andrew S., Handelsman J. Diverse antibiotic resistance genes in dairy cow manure. MBio 5: e01017. 2014: http://mbio.asm.org/content/5/2/e01017–13.short.
17. Santamaría J., López L., Soto C.Y. Detection and diversity evaluation of tetracycline resistance genes in grassland-based production systems in Colombia, South America. Front Microbiol 2. 2011: http://www.ncbi.nlm.nih.gov/pubmed/22174707.
Review
For citations:
Boiko T.V., Gerunova L.K. THE ANALYSIS OF CHEMATHERAPEUTIC AGENTS APPLIED IN DAIRY ANIMAL BREEDING OF RUSSIA. Bulletin of NSAU (Novosibirsk State Agrarian University). 2016;(4):91-96. (In Russ.)