SUBALINE INFLUENCE ON LYMPH GLAND MORPHOLOGY AND HEMATOLOGICAL PARAMETERS OF BALB/C MICE INFECTED BY RAUSCHER VIRUS
Abstract
The paper demonstrates morphological changes in peripheral blood and lymph glands of BALB/c mice infected by Rauscher virus and influenced by Subaline. Rauscher virus is fatal for animals and application of Subaline hasn’t extended lifetime of infected mice. Rauscher virus causes erythropenia and leucopenia in hyperplastic disease period. The authors observed leucocytes regain in infected mice in the end-stage. Subaline affects hematological parameters regain and leykocytopoiesis in the mice infected by Rauscher virus. Rauscher virus causes transporting functional depression and lymph proplasia in the early hyperplastic period. Immune suppression occurs in the end stage of the disease. The article makes the case about application of Subaline in the early stage to the mice infected by Rauscher virus and outlines reducing of lymph B-zone and transporting functional enhancement. The end-stage is characterized by B-zone activation when the number of antibodies is increasing influenced by Subaline.
About the Authors
Ia. L. Rusakova
Новосибирский НИИ патологии кровообращения им. акад. Е. Н. Мешалкина
Russian Federation
Russian Federation
S. N. Mager
Новосибирский государственный аграрный университет
Russian Federation
Russian Federation
V. V. Khramtsov
Институт экспериментальной ветеринарии Сибири и Дальнего Востока
Russian Federation
Russian Federation
References
1. Petrov R. V. Immunologiya. Moscow: Meditsina, 1987. 416 p.
2. Sapin M. R., Etingen L. E. Immunnye sistemy cheloveka. – Moscow: Meditsina, 1996. 301 p.
3. Smirnov P. N., Khramtsov V. V., Smirnova V. V. Prakticheskie aspekty leykoza krupnogo rogatogo skota [Veterinariya], no. 8 (1998): 6.
4. Bergol’ts V.M., Kislyak N. S., Eremeev V. S. Immunologiya i immunoterapiya leykoza. Moscow: Meditsina, 1978. 404 p.
5. Gabrilovich D. I., Patterson S., Harvey J. J. et al. Murine retrovirus induces defects in the function of den-dritic cells at early stages of infection. Cell. Immunol., no. 158 (1994): 167–181.
6. Naniche D., Oldstone M. Generalized immunosuppression: how viruses undermine the immune response. CMLS, Cell. Mol. Life Sci., no. 57 (2000): 1399–1407.
7. Mechetner E. B., Ievleva E. S., Rozinova E. N. i dr. Svoystva i identifikatsiya klonogennykh kletok leykoza Raushera [Probl. gematologii], no. 9 (1979): 51–59.
8. Metodicheskie rekomendatsii po opredeleniyu antitel k VLKRS metodom immunofermentnogo analiza. Moscov: VIEV, 1983.
9. Rassulin Yu.Yu., Fedorova N. A., Rechinskiy V. O., Parfanovich M. I. Obnaruzhenie provirusa leykoza krupnogo rogatogo skota v leykotsitakh perifericheskoy krovi krupnogo rogatogo skota metodom DNK-gibridizatsii [Vopr. virusologii], no.1 (1988): 58–63.
10. Carli K. T., Batzman H., Sen A., Minbay. Comparison of serum, milk and urinosamples in an enzime em-munoassay for bovine leukemia virus infection. Resaerch in Veterinary Science, no. 55 (1993): 394–395.
11. Al’tshteyn A.D., Valikhov A. F. Podkhody k zhivoy vaktsine protiv bych’ego leykoza na osnove virusa ospovaktsiny [Novye napravleniya biotekhnologii: tez. dokl. 5-y konf. Ros. Federatsii, Pushchino, 18–22 maya 1992]. 1992. pp. 52.
12. Mager S. N. Biologicheskaya kharakteristika potomstva zdorovykh i bol’nykh leykozom korov i assotsiativnoe razvitie leykoza i tuberkuleza u zhivotnykh [Avtoref. dis. … d-ra biol. nauk]. Novosibirsk, 2006. 40 p.
13. Mazurenko N. P., Revazova E. S. Vaktsinatsiya myshey protiv nekotorykh virusov leykozov. Riga, 1970. pp. 421–428.
14. Parfanovich M. I., Simonyan G. A., Lazarenko A. A. i dr. Issledovanie inaktivirovannoy tsel’novirionnoy vaktsiny iz virusa leykoza krupnogo rogatogo skota [Tez. dokl. Vsesoyuz. konf. 9–11 okt. 1984 g. UNIVI]. Tashkent, 1984. pp. 159.
15. Sabashvili M. Stimulyatsiya obrazovaniya endogennogo interferona u myshey i ego vliyanie na eksperimental’nuyu virusnuyu leykemiyu [Rasprostranenie, virusologiya i immunologiya leykozov cheloveka i zhivotnykh]. Riga, 1970. pp. 443–449.
16. Miller J. Bovine leukemia virus vaccine. Anim. Models of Retrov. Inf. and their Relationship to AIDS, 1987. pp. 421–430.
17. Ohishi K., Maruyama T., Shida H. et al. Immunogenicity of a recombinant vaccinia virus expression envelop glycoprotein of bovine leukemia virus. Vaccine. Vol. 6, no. 5 (1988): 428–432.
18. Onuma M., Hodatsu T., Yamamoto S. et al. Protection by vaccination against bovine leukemia virus infection. Amer. J. Vet. Res., no. 6 (1984): l212–1215.
19. Patrascu I., Coman S., Sandu I. et al. Specific protection against bovine leukemia virus infection conferred on cattle by the Romanian inactivated vaccine BL–VACC-RO. Rev. Roum. Med. Virol., no. 2 (1980): 95–102.
20. Portetelle D., Limback K., Burny A. Recombinant vaccinia virus expression of the bovine leucosis virus env gene. Vaccine, no. 9 (1990): 194–200.
21. Belyavskaya V. A., Kashperova T. A., Bondarenko V. M. i dr. Eksperimental’naya otsenka biobezopasnosti genno-inzhenernykh bakteriy na modeli shtamma Bacillus subtilis, produtsiruyushchego interferon [Zhurn. mikrobiologii], no. 2 (2001): 16–20.
22. Belyavskaya V. A., Cherdyntseva N. V., Bondarenko V. M. i dr. Biologicheskie effekty interferona, produtsiruemogo rekombinantnymi bakteriyami preparata-probiotika subalina [Zhurn. mikrobiologii], no. 2 (2003): 102–109.
23. Bondarenko V. M., Belyavskaya V. A. Klonirovanie i ekspressiya genov v molochnokislykh bakteriyakh [Zhurn. mikrobiologii], no. 2 (2000): 67–73.
24. Bondarenko V. M., Rubakova E. I., Lavrova V. A. Immunomoduliruyushchee deystvie laktobakteriy, ispol’zuemykh v kachestve osnovy preparatov probiotikov [Zhurn. mikrobiologii], no. 5 (1998): 107–112.
25. Grachev A. Yu., Adov S. A., Vasil’ev A. N. Eksperimental’naya otsenka vliyaniya aerogennogo khronicheskogo postupleniya B. subtilis na nekotorye pokazateli immuniteta [Materialy yubil. nauch. konf., posvyashch. 50-letiyu Tsentra VTP BZ NII mikrobiologii MO RF]. Ekaterinburg, 1999. pp. 50–51.
26. Zhdanov P. I. Primenenie sporobakterina dlya povysheniya sokhrannosti i produktivnosti sviney [Veterinariya], no. 11 (1994): 36–40.
27. Miroshnikov S. A., Sipaylova O. Yu. Sravnitel’naya morfofunktsional’naya kharakteristika organov immunnoy sistemy ptits pri skarmlivanii fermentnogo preparata i probiotika na osnove kul’tury B. subtilis [Vestn. OGU], no. 5 (2006): 232–234.
28. Smirnov V. V., Reznik S. R., V’yunitskaya V.A. i dr. Sovremennye predstavleniya o mekhanizmakh lech-ebno-profilakticheskogo deystviya probiotikov iz bakteriy roda Bacillus [Mikrobiol. zhurn], T. 55, no. 4 (1993): 92–107.
29. Sorokulova I. B., Belyavskaya V. A., Masycheva V. I. i dr. Rekombinantnye probiotiki: problemy i perspektivy ispol’zovaniya dlya meditsiny i veterinarii [Vestn. RAMN], no. 3 (1997): 46–49.
30. Rusakova Ya.L., Mager S. N., Khramtsov V. V. Vliyanie virusa leykoza Raushera na gematologicheskie pokazateli i morfologiyu limfaticheskikh uzlov eksperimental’nykh myshey linii BALB/c [Vestn. NGAU], no. 3 (32) (2014): 104–109.
31. Morse B., Giuliani D., Fredrickson T., LoBue J. Erythrokinetics and ferrokinetics of a viral-induced mu-rine erythroblastosis. Blood. Vol. 51 (4) (1978): 623–32.
32. Sokolov P. P. Bergol’ts V.M. A peculiarity in the humoral immunity of BALB/C mice with Rauscher leukemia. Bull. Eksp. Biol. Med. Vol. 81 (3) (1976): 356–358.
33. Volkova O. V., Eletskiy B. K. Osnovy gistologii i gistologicheskoy tekhniki. Moscow: Meditsina, 1971. pp. 242–253.
34. Romeys B. Mikroskopicheskaya tekhnika. Moscow: Inostr. lit., 1954. 718 p.
35. Stefanov S. B. Vizual’naya klassifikatsiya pri kolichestvennom sravnenii izobrazheniy [Arkhiv anatomii, gistologii i embriologii], T. 88, vyp. 2 (1985): 78–83.
36. Mezhdunarodnaya gistologicheskaya nomenklatura. Pod obshch. red. Yu.I. Afanas’eva. 5-e izd. Moscow: Meditsina, 1987. pp. 128.
37. Abramov M. G. Gematologicheskiy atlas. Moscow: Meditsina, 1985. 344 p.
38. Katinas G. S., Lyashko O. G., Bazhenova I. A. Dinamika kolichestva kletok limfoidnogo ryada v parakortikal’noy zone limfaticheskikh uzlov u myshey S57V1 [Vremennaya i prostranstvennaya organizatsiya tkaney]. L.: Izd-vo 1-go LMI, 1981. pp. 47–54.
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For citations:
Rusakova I.L., Mager S.N., Khramtsov V.V. SUBALINE INFLUENCE ON LYMPH GLAND MORPHOLOGY AND HEMATOLOGICAL PARAMETERS OF BALB/C MICE INFECTED BY RAUSCHER VIRUS. Bulletin of NSAU (Novosibirsk State Agrarian University). 2015;(3):90-98. (In Russ.)
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