ASSOCIATION OF POLIMORPHISM –824OF А/G OF THE GENE OF TUMOR NECROSIS FACTOR ALPHA WITH CALF GROWTH INDICES

The paper provides research data on the search for genetic markers of Red Steppe animals growth and development. The indices are the ones of the most important breeding traits which influence the formation of constitution, exterior, productivity and vitality of animals. High rate of growth in the early postnatal period is preferable in economic terms. However, at present, there is a problem of heavy calving. As a consequence, the cows cannot recover long, they cannot fully realize their potential of productivity. The gene of tumor necrosis factor alpha codes for the multifunctional protein which, concurrently with immune response functions, plays an important part in general metabolism. Polymorphism –824 A/G of the gene of tumor necrosis factor alpha is examined with the method of polymerase chain reaction with concomitant analysis of restriction fragments lengths in the herd of Red Steppe cow breeds at the agricultural artel of the breeding-farm “Stepnoy” of German national district in Altai Krai. The frequency of the rare allele A in the sample of 57 animals examined made up 25%. Distribution of genotypes frequency corresponded to Hardy-Weinberg equilibrium A true association of G/A genotype is established with decreased weight of calves at birth (p<0.05). No true differences among the animals with different genotypes were revealed in the sample concerned for the indices of average daily and relative gains.

Red Steppe breed, polymorphism, tumor necrosis factor alpha, TNF-α, gain, weight at birth

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