ASSOCIATION OF RECIPROCAL TRANSLOCATION RCP (13; 26) (Q24; Q11) WITH UNSTABLE GENOME OF THE CATTLE SOMATIC CELLS

Abstract

The paper explores somatic chromosome instability of Holstein black-and-white healthy cows when an animal was a carrier of reciprocal translocation rcp (13; 26) (q24; q11). The researchers observed high frequency of chromosome mutations of translocation carrier compared with half-sibs (P < 0.05-0.01) and herdmates (P < 0.05-0.001). Frequency of chromosome fragments of translocation carrier was 3 times higher than that of animals of the control group (P < 0.01). The authors found out that multiaberrant cells containing two and more chromosome mutations of translocation carrier tend to be increased. Reciprocal translocation can be followed by growth of triploid chromosomes and this is not common for spontaneous mutagenesis. The research investigated aneuploid cells and revealed high features of herdmates and half-sibs compared with mutation carrier (P < 0.01). The significant differences are explained by high frequency of hypoploid cells and exactly frequency of cells with deficiency chromosome (P < 0.01). The authors suppose, that reciprocal translocation carrier suffers from reparative system of DNA damages that doesn’t lead to elimination of mutation cells.