Influence of transcranial electrical stimulation on repair processes in rats
https://doi.org/10.31677/2072-6724-2025-74-1-215-224
Abstract
The studies were carried out to study the effect of transcranial electrical stimulation of the antinociceptive system of the brain on the healing process of skin wounds in laboratory animals. Object of study: non-linear white male laboratory rats in the amount of 80 animals. In the first experimental group, a transcranial electrical stimulation mode was used in the form of a combination of direct and alternating currents with analgesic parameters. In the second and third experimental groups, the same combination was used, but with different pulse frequencies - 50 and 90 Hz («frequencies of non-analgesic stimulation»). Sessions of transcranial electrical stimulation were carried out once a day for 30 minutes for three days after the application of skin wounds. Additionally: for three days before the wound and three days after the operation («preventive» and “therapeutic» effects): both analgesic and non-analgesic modes of electrical influence were used. Under the influence of transcranial electrical stimulation with analgesic current parameters (frequency 70 Hz), a significant acceleration (by 21%) of the healing process and a reduction in the average time for complete wound healing are observed. Transcranial impacts with «non-analgesic stimulation frequencies» (50 and 90 Hz) did not cause any changes in the rate of healing, compared to the control. The greatest acceleration of wound healing under the influence of medical procedures is reliably manifested on days 4-7 after their application, and in the control group on days 10-11. In the «preventive» group, the change in wound size was significantly faster than that in rats with the «therapeutic» effect: on the 4th day, the difference in the area of wounds between the experimental groups and the control was statistically significant and amounted to 12%, while the «therapeutic» effect On the 8th day it achieves a similar result.
About the Authors
M. A. Uryadnikov
FSBEI HE Irkutsk State Agrarian University named after A.A. Ezhevsk
Russian Federation
Russian Federation
postgraduate student
Molodezhny
D. V. Dashko
FSBEI HE Irkutsk State Agrarian University named after A.A. Ezhevsk
Russian Federation
Russian Federation
candidate of veterinary sciences, associate professor
Molodezhny
References
1. Veselova F.A., Dashko D.V., Rol’ agrarnoy nauki v ustoychivom razvitii sel’skikh territoriy (The role of agricultural science in the sustainable development of rural areas), Collection of the VII All-Russian (national) scientific conference with international participation, Novosibirsk, 2022, pp. 372–374. (In Russ.)
2. Dashko D.V., Ippologiya i veterinariya, 2023, No. 1(47), pp. 129–137, DOI: 10.52419/2225-1537/2023.1.129-137. (In Russ.)
3. Dashko D.V., Treatment of purulo-necrotic pathology complicated by associated bacterial microflora in the hoof area in cows, E3S Web of Conferences, 2021, pp. 09015, DOI: 10.1051/e3sconf/202125409015.
4. Silkin I.I., Batomunkuev A.S., Dashko D.V., Tarasevich V.N., Morphofunctional changes in rabbit thymus with simultaneous vaccination and disinsection, IOP conference series: earth and environmental science: Agriculture, field cultivation, animal husbandry, forestry and agricultural products Ser. 2, 2021, Vol. 723, pp. 022060, DOI: 10.1088/1755-1315/723/2/022060.
5. Dashko D.V., Vestnik IrGSKHA, 2013, No. 58, pp. 102–108. (In Russ.)
6. Kucharski P., Antończyk A., Prządka P., Liszka B., Lachowska S., Kiełbowicz Z., Clinical usefulness of the anaesthetic protocol using low doses of Tiletamine – Zolazepam combination in continuous rate infusion as a partial intravenous anaesthesia in bitches undergoing laparoscopic surgery, Topics in Companion Animal Medicine, 2022, Vol. 49, pp. 100664, DOI: 10.1016/j.tcam.2022.100664.
7. Dashko D.V., Vestnik IrGSKHA, 2013, No. 57–3, pp. 59–66. (In Russ.)
8. Dashko D.V., Byambaa B., Treatment of purulent-necrotic diseases of the distal region of limbs complicated by bacterial microflora in cattle, Vestnik IrGSHA, 2020, No. 101, pp. 128–134, DOI: 10.51215/1999-3765-2020-101-128-134.
9. Dashko D., Silkin I., Effect of transcranial electrotherapy stimulation on reparative regeneration of the damaged sciatic nerve in the experiment, E3S Web of Conferences, 2021, pp. 08010, DOI: 10.1051/e3sconf/202125408010.
10. Dashko D.V., Silkin I.I., Relevance of the use of postmortem biomaterial of domesticated yak (Bos grunniens) to obtain stem cells from bone marrow, Siberian Journal of Life Sciences and Agriculture, 2023, Vol. 15, No. 2, pp. 11–23, DOI: 10.12731/2658-6649-2023-15-2-11-23.
11. Dashko D.V., Nauchnyye issledovaniya i razrabotki k vnedreniyu v APK (Scientific research and development for implementation in the agricultural sector), Proceedings of the International Scientific and Practical Conference of Young Scientists, Irkutsk, 2013, pp. 183–187. (In Russ.)
12. Dashko D.V., God nauki i tekhnologiy 2021 (Year of Science and Technology 2021), Collection of abstracts based on the materials of the All-Russian Scientific and Practical Conference, Krasnodar, 2021, pp. 43. (In Russ.)
13. Dashko D.V., Aktual’nyye voprosy agrarnoy nauki, 2013, No. 6, pp. 27–32. (In Russ.)
14. Dashko D., Tarasevich V., Melnik O., Experimental and clinical justification of male orchidectomy under local anesthesia in combination with xylazine and subanesthetic doses of zoletil, E3S Web of Conferences, 2020, pp. 2027, DOI: 10.1051/e3sconf/202022202027.
15. Dashko D.V., Batomunkuev A.S., Vestnik Buryatskoy gosudarstvennoy sel’skokhozyaystvennoy akademii im. V.R. Filippova, 2020, No. 4(61), pp. 159–163, DOI: 10.34655/bgsha.2020.61.4.024. (In Russ.)
16. Dashko D.V., Meltsov I.V., Morfologiya, 2020, T. 157, No. 2–3, pp. 68. (In Russ.)
17. Silkin I.I., Batomunkuev A.S., Dashko D.V., Tarasevich V.N., Electron-microscopic study of enterocytes of intestinal crypts of the small intestine of a hybrid of a yak (Bos mutus) with a cow of a black-and-white Holstein breed, IOP Conference Series: Earth and Environmental Science: Mechanization, engineering, technology, innovation and digital technologies in agriculture Ser. 3, IOP PUBLISHING LTD, 2021, pp. 032084, DOI: 10.1088/1755-1315/723/3/032084.
18. Dashko D.V., Nachatov N.Ya., Darbinyan A.A., Aktual’nyye voprosy veterinarnoy meditsiny (Current issues of veterinary medicine), Materials of the Russian Scientific and Practical Conference, Novosibirsk, 2003, pp. 9–11. (In Russ.)
19. Dashko D.V., Silkin I.I., Uryadnikov M.A., Problemy i perspektivy ustoychivogo razvitiya agropromyshlennogo kompleksa (Problems and prospects for the sustainable development of the agro-industrial complex), Materials of the All-Russian scientific and practical conference with international participation, dedicated to the memory of Alexander Alexandrovich Ezhevsky, Irkutsk, 2023, pp. 77–83. (In Russ.)
20. Silkin I.I., Popov A.P., Dashko D.V., Prospects for using post-mortal genetic materials on the example of sable to ensure the biodiversity in natural systems, IOP conference series: earth and environmental science: The conference proceedings, IOP Publishing Ltd, 2019, Vol. 395, pp. 012019, DOI: 10.1088/1755-1315/395/1/012019.
21. Inyusheva A.I., Dashko D.V., Klimat, ekologiya, sel’skoye khozyaystvo Yevrazii (Climate, ecology, agriculture of Eurasia), materials of the XI International Scientific and Practical Conference, Irkutsk, 2022, pp. 430–437. (In Russ.)
22. Kravchenko A.A., Dashko D.V., Nauchnyye issledovaniya studentov v reshenii aktual’nykh problem APK (Scientific research of students in solving current problems of the agro-industrial complex), Materials of the All-Russian Student Scientific and Practical Conference, Irkutsk, 2023, pp. 59–62. (In Russ.)
23. Loguntsova M.S., Dashko D.V., Aktual’nyye problemy veterinarnoy nauki i praktiki (Current problems of veterinary science and practice), Collection of materials of the All-Russian (national) scientific and practical conference, Omsk, 2021, pp. 41–44. (In Russ.)
24. Loguntsova M.S., Dashko D.V., Aktual’nyye problemy veterinarnoy nauki i praktiki (Current problems of veterinary science and practice), Collection of materials of the All-Russian (national) scientific and practical conference, Omsk, 2021, pp. 136–139. (In Russ.)
25. Loguntsova M.S., Dashko D.V., Klimat, ekologiya, sel’skoye khozyaystvo Yevrazii (Climate, ecology, agriculture of Eurasia), Proceedings of the X International Scientific and Practical Conference, 2021, pp. 114–115. (In Russ.)
26. Marchuk T.N., Dashko D.V., Vyzovy i innovatsionnyye resheniya v agrarnoy nauke (Challenges and innovative solutions in agricultural science), Proceedings of the XXVII International Scientific and Industrial Conference, Mayskiy, 2023, Vol. 2, pp. 149–150. (In Russ.)
27. Marchuk T.N., Dashko D.V., Vyzovy i innovatsionnyye resheniya v agrarnoy nauke (Challenges and innovative solutions in agricultural science), Proceedings of the XXVII International Scientific and Industrial Conference, Mayskiy, 2023, Vol. 2, pp. 147–148. (In Russ.)
28. Mukhametdinova A.V., Dashko D.V., Nauchnyye issledovaniya studentov v reshenii aktual’nykh problem APK (Scientific research of students in solving current problems of the agro-industrial complex), Materials of the All-Russian student scientific and practical conference, Irkutsk, 2023, pp. 80–83. (In Russ.)
29. Silkin I.I., Dashko D.V., Uryadnikov M.A., Klimat, ekologiya i sel’skoye khozyaystvo Yevrazii (Climate, ecology and agriculture of Eurasia), Materials of the XII international scientific and practical conference, Molodezhny village, 2023, pp. 303–307. (In Russ.)
Review
For citations:
Uryadnikov M.A., Dashko D.V. Influence of transcranial electrical stimulation on repair processes in rats. Bulletin of NSAU (Novosibirsk State Agrarian University). 2025;(1):215-224. (In Russ.) https://doi.org/10.31677/2072-6724-2025-74-1-215-224
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