Effect of oregano and marsh cinquefoil extracts on the morphofunctional characteristic of mice liver tissues under acute stress

The aim of the study was to investigate the effect of extracts of medicinal plants oregano (O) and marsh cinquefoil (MC) on the morphofunctional state of liver tissue in mice using the acute stress model. The object of the study was 60 laboratory mice of different sexes of the CD-1 line. A total of 6 experimental groups were formed, with 10 individuals in each: 1 control group with a standard diet (SD); 2 SD + 20 ml / kg live weight daily MC extract; 3 SD + 20 ml / kg O extract; 4 SD + stress exposure; 5 SD + stress exposure + 20 ml / kg MC extract; 6 SD + stress exposure + 20 ml / kg O extract. The results of the study showed that the action of biologically active substances in the MC and O extracts can be factors of low antigen load, indirectly increasing the functional activity of liver cells. Specific morphophysiological changes in the liver of animals with the induced stress model give grounds to believe in the presence of a free radical mechanism of damage to the cells of this organ. In the liver samples of animals with the stress model and the introduction of the MC extract into the body, a lower level of damage to hepatocytes was found in comparison with similar samples of animals with the stress model and a standard diet. The level of damage to the liver parenchyma cells in them was limited by a reversible process hydropic dystrophy of hepatocytes. When combining the processes of stress modeling and the implementation of the O extract, the active substances of the extract directly or indirectly reduced the level of damage to the structural components of the cell. In general, the obtained results allow us to conclude that the MC and O extracts have adaptogenic properties and are promising for further study as independent and complex herbal drugs.

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