Current pathogenicity factors of viral and bacterial pathogens of young cattle

Infectious pathologies of animals remain the main problem on the path of high productivity, preservation and, as a result, productive longevity of animals and ultimately determines the profitability of agricultural industrial production of animal products. The possibility of developing pathologies is caused by specific substances of predominantly organic origin (proteins, enzymes, toxins, glycopeptides, etc.), which cause a set of highly specific pathogenic properties of microorganisms. In this connection, there is a growing interest and need to study the pathogenic properties of viruses and bacteria, which cause a number of mechanisms that ensure the neutralization of protective immune mechanisms of animals (adhesive, anti-complementary, anti-lactoferin, antihemoglobin, anti-lysozyme activity, biofilm formation, antibiotic resistance, etc.). The study and development of effective methods to counteract these pathogenicity factors is possible only taking into account the study and search for the practical application of specific substances in the form of vaccines and drugs. Numerous studies of infectious agents causing pathology of the gastrointestinal tract with diarrhea syndrome in calves, according to statistics, distinguish the most common bovine rotavirus, bovine coronavirus, bovine viral diarrhea virus, bovine calicivirus and bovine torovirus, as well as bacteria Salmonella spp., E. coli, C. perfringens and C. parvum. The data from the review of the pathogenicity factors of bacteria and viruses show their diversity, which causes various forms of the course and manifestations of infectious pathologies. Monitoring and further study of the antigenic profile of infectious pathogens allows timely development of relevant diagnostic methods for their identification. The study of protein antigenic proteins makes it possible to develop means for the treatment and prevention of infectious animal diseases.

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