Development of a device for photodynamic therapy
https://doi.org/10.31677/2072-6724-2024-70-1-246-252
Abstract
The research was carried out at the laboratory of reproduction and adaptation of farm animals of the Siberian Federal Scientific Center for Agrobiotechnologies of the Russian Academy of Sciences (SFSC RAS). Photodynamic therapy makes it possible to locally activate the photosensitizer concentrated in the tumor or tube with visible light, which leads to a photochemical reaction that destroys tumor cells and tumors in the development of the disease. A design has been developed, and a laboratory sample of a device for irradiating photosensitizers and conducting photodynamic therapy has been created. The device can be used for experimental work in biology, veterinary medicine, and medicine to study the effectiveness of photosensitizers and the therapeutic effects of photosensitizers in diseases, including those caused by opportunistic microflora. The device can be used to carry out work on photodynamic therapy both in laboratory and field conditions by irradiating biological objects that have previously been exposed to photosensitizers due to the device’s ability to generate optical monochrome radiation with wavelengths of 660, 610, 430, and 395 nm with the ability to adjust the power of optical radiation and its modulation with a frequency in the range from 0 to 25000 Hz, which allows the use of a wide range of photosensitizers. The technical solution of the device for irradiating photosensitizers and conducting photodynamic therapy is protected by copyright - utility model patent No. 191736 U1 Russian Federation, IPC A61N 5/06.
About the Authors
A. V. Pavlov
Novosibirsk State Technical University
Russian Federation
Russian Federation
A.V. Pavlov, PhD in Biological Sciences
Novosibirsk
E. Y. Smertina
Siberian Federal Scientific Center for Agrobiotechnologies RAS
Russian Federation
Russian Federation
E.Y. Smertina, Doctor of Veterinary Sciences
Novosibirsk
N. N. Gorb
Novosibirsk State Agrarian University
Russian Federation
Russian Federation
N.N. Gorb, PhD in Veterinary Sciences
Novosibirsk
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Review
For citations:
Pavlov A.V., Smertina E.Y., Gorb N.N. Development of a device for photodynamic therapy. Bulletin of NSAU (Novosibirsk State Agrarian University). 2024;(1):246-252. (In Russ.) https://doi.org/10.31677/2072-6724-2024-70-1-246-252
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