CHARACTERISTIC OF LIVER FERMENTEMIA UNDER THE CONDITIONS OF MICE CADMIUM INTOXICATION

Abstract

The paper studies changes in the activity of enzymes (aspartate aminotransferase, AsAT), alanine aminotransferase, AlAT), alkaline phosphatase, AP), gamma-glutamate transferase, γ-GTF) in mice’s liver supernatant in the background of cadmium intoxication. It was identified that in the background of daily receiving cadmium sulfate per os at the dose of 40 mg/animal, liver weight goes down (significantly from the 3rd day of the intoxication), fermentemia progresses with its maximal expression determined both by the time of exposition to the toxicant in the body and the role of fermentative reactions catalyzed by AsAT, AlAT, AP and γ-GTF to maintain metabolic flows in the cells of the liver and body on the whole. Thus, the activity of aminotransferases in the liver supernatant maximally increases the day after the intoxication start reflecting the level of catabolic processes; that of alkaline phosphatase - on the third day characterizing the level of power deficit; γ-GTF - on the eighth day determining the degree of amino acids borrowed from the body tissues. Fermentemia is the index of liver compensatory possibilities and dynamics of pathological changes.