Anatomy and histology of the thymus of American mink genotypes Standard, Sapphire, Lavander in the early postnatal period of ontogenesis

Data are presented on the thymus structure of American Mink of the Standard, Sapphire, Lavender colouring genotypes in the early postnatal period from birth to 180 days. The thymus is known to be a fully formed organ at birth. The anatomical structure of the thymus and its topography are not determined by genotype. At 45 days of age, the changes are manifested by an increase in the thymic lobule area and the brain matter therein, a decrease in the cortex area; the most intense growth of the thymus due to the rise in the number of lobules is noted. The thymus of mink at 45 to 90 days of age is characterised by an equalisation between the genotypes, increasing cortical area values to about the level of newborn mink with a corresponding increase in the cortical-brain index. The thymus of minks at the age of 90 to 180 days retains the typical morphological structure. Still, the signs of age involutive processes are seen – reduction of the lobule area, enlargement of the medulla, changes in the form of the organ (lobule fusion), increased signs of fat transformation thymus. Hassall’s corpuscles were found in the medulla in all periods of investigation. The number of Hassall’s bodies and their morphology depends on the functional activity of the thymus. In newborns, unicellular, young and juvenile forms predominate. In 45-day-old minks, young and immature forms predominate. In 90-day-old female and male Standard burros, young and quite often unicellular bodies are visualised, while mature and juvenile records are less common. In mink of the coloured genotypes, immature and youthful Hassall’s corpuscles are predominant. By 180 days, the number of mature and young corpuscles with signs of central cell destruction with detritus accumulation and cavity formation increases.

1. Kuz’menko L.G., Kiselev. N.M., Simonova A.V, Zdorov’e i obrazovanie v XXI veke, 2013, Т.15, No.1, pp. 170–175. (In Russ.)

2. Baimishev Kh.B., Krishtoforova B.V., Khrustaleva I.V., Lemeshchenko V.V., Stegnei Zh.G., Biologicheskie osnovy veterinarnoi neonatologii (Biological bases of veterinary neonatology), Samara: SGSKhA, 2013, 452 p.

3. Tumilovich G.A., Molodezh’ i innovatsii – 2013 (Youth and innovation – 2013), Proceedings of the international scientific and practical conference of young scientists, Gorki: BGSKhA, 2013, part 3, pp. 323–326. (In Russ.)

4. Silant’eva I.V., Rovda Yu.I., Bad’ina O.S., Khasanova G.A., Mat’ i Ditya v Kuzbasse, 2011, No. 2, pp. 11–16. available at: https://mednauki.ru/index.php/MD/issue/viewIssue/43/42 (August 22, 2021)

5. Kharchenko V.P., Sarkisov D.S., Vetshev P.S., Zairat’yants O.V., Bolezni vilochkovoi zhelezy (Diseases of the thymus gland), Moscow: Triada-Kh, 1998, 232 p.

6. Bikteev Sh.M., Seitov M.S., Izvestiya OGAU, 2007, No. 15-1, pp. 122 – 125, available at: https:// cyberleninka.ru/article/n/morfo-funktsionalnye-osobennosti-vilochkovoy-zhelezy-kozy-orenburgskoy-puhovoy-porody-v-ontogeneze-v-norme-i-pri-mikointoksikatsii (August 22, 2021).

7. Gazizova A.I., 3i: intellect, idea, innovation – intellekt, ideya, innovatsiya, 2016, No. 1, pp. 3136, available at: http://3i.ksu.edu.kz/files/3i/3i-1-2016-1.pdf (August 22, 2021).

8. Fisenko S.P., Morfologicheskaya kharakteristika shchitovidnoi zhelezy i timusa molodnyaka krupnogo rogatogo skota cherno-pestroi porody (Morphological characteristics of the thyroid gland and thymus of young black-and-white cattle), Extended abstract of candidate’s thesis, Saransk, 2009, 23 p., available at: https://viewer.rusneb.ru/ru/rsl01004609686?page=1&rotate=0&theme= white (August 21, 2021).

9. Faizova G.M., Sitdiov R.I., Karimova A.Z., Sovremennye problemy anatomii, gistologii i embriologii zhivotnykh (Modern problems of animal anatomy, histology and embryology): Proceedings of the 3rd All-Russian Internet-Conference, April, 03–06, 2012, Kazan’: IP Sinyaev D.N., 2012, pp. 122–123, available at: https://www.elibrary.ru/item.asp?id=21610779 (August 21, 2021).

10. Freidlin I.S., Sorosovskii obrazovatel’nyi zhurnal, No. 5, 1997, pp. 26–29, available at: http:// www.pereplet.ru/nauka/Soros/pdf/9705_026.pdf (August 21, 2021).

11. Rozhkova I.S., Teplyi D.L., Fel’dman B.V., Trizno M.N., Astrakhanskii meditsinskii zhurnal, 2013, Vol. 8, No. 1, pp. 211–214. available at: https://www.elibrary.ru/item.asp?id=19144003 (August 21, 2021).

12. Zairat’yants O.V., Arkhiv patologii, 1991, No. 10, pp. 3–12. (In Russ.)

13. Tsybikova R.N., KrasGAU, 2007, No. 4, pp. 107-113, available at: https://cyberleninka.ru/article/n/gistostruktura-timusa-yakov-buryatskogo-ekotipa-v-postnatalnom-ontogeneze (August 21, 2021).

14. Yurchinskii V.Ya., Vestnik novykh meditsinskikh tekhnologii, 2015, No. 3 available at: http://www.medtsu.tula.ru/VNMT/Bulletin/E2015-3/5176.pdf (August 21, 2021).

15. Usenko V.I., Konstantinova I.S., Bulatova E.N., Uchenye zapiski KGAVM im. N.E. Baumana, 2010, Vol. 201, pp. 343–347, available at: https://kazanveterinary.ru/science-innovation/scientific-notes/ (August 21, 2021).

16. Khodusov A.A., Ponomarenko M.E., Kvochko A.N., Skripkin V.S., Konoplev V.I., Izvestiya Orenburgskogo gosudarstvennogo agrarnogo universiteta. 2019, No. 1 (75), pp. 185–189. (In Russ.)

17. Moroz G.A., Morfologiya, 2010, Vol. IV, No. 3, pp. 23–27. (In Russ.)

18. Parfenyuk I.N., Patomorfologiyaimmunnoi sistemy pri zhirovom gepatoze norok (Pathomorphology of the immune system in fatty hepatosis of mink), Extended abstract of candidate’s thesis, Saint Petersburg, 2004, 24 p., available at: htttps://viewer.rusneb.ru/ru/rs101004609686?page=1&rotat e=0&theme=white (August 21, 2021).