DYNAMICS OF CHANGES IN QUANTITATIVE INDICATORS OF WHITE BLOOD IN CATS WITH THE COMBINED USE OF THE DRUGS HEMOBALANCE AND VETOM 1

The effect of the complex vitamin-mineral preparation Hemobalance for the optimization of hematopoietic processes in animals during complex restorative therapy and the probiotic preparation Vetom 1, containing at least 1ˑ106 CFU / g of Bacillus subtillis microorganisms, strain DSM 32424, on the concentration of leukocytes and lymphocytes in the blood of Abyssinian cats was studied. 10 cats of the Abyssinian breed were involved in the study of this drug. They were kept at home, having the same diet as cats with liver and pancreas pathologies. The cats were divided into 2 groups (control and experimental), 5 animals each. The experimental group of cats was given the probiotic preparation Vetom 1 based on apathogenic bacilli at a dose of 50 mg / kg once a day every day for 30 days per os. Additionally, the cats of both groups were injected intramuscularly with the complex drug Hemobalance for 30 days at a dose of 0.25 ml. The study of hematological blood parameters was carried out on an automatic closed-type hematology analyzer Vet Auto Hematology Analyzer BC2800. In the course of our research, it was found that under the influence of the probiotic preparation Vetom 1, the concentration of blood leukocytes decreases within the physiological norm. Additional use of Hemobalance does not change this trend.

probiotic, Vetom 1, hemobalance, cats, lymphocytes, leukocytes, relative concentration, absolute concentration, Abyssinian cats

1. Karpenko L.Yu., Andreeva A.B. Voprosy normativno-pravovogo regulirovaniya v veterinarii, 2009, No. 1-2, pp. 109-111 (In Russ.)

2. Plemyashov K.V. Veterinariya, 2009, No. 2, pp. 14-16 (In Russ.)

3. Plemyashov K.V. Veterinariya, 2010, No. 8, pp. 56-59 (In Russ.)

4. Nechaeva T.A. Voprosy normativno-pravovogo regulirovaniya v veterinarii, 2010, No. 3, pp. 50-53 (In Russ.)

5. Khazimukhametova I.F., Vasil’eva I.A., Shishkina E.A. Dostizheniya nauki i tekhniki APK, 2013, No. 8, pp. 57-59 (In Russ.)

6. Rudenko P.A., Rudenko V.B., Rudenko A.A. Vestnik Mariyskogo gosudarstvennogo universiteta., 2019, Vol. 5, No. 1, pp. 42-49 (In Russ.)

7. Nozdrin G.A., Ivanova A.B., Nozdrin A.G. Vestnik NGAU, 2011, No. 5(21), pp. 87-95 (In Russ.).

8. Tarakanov B.V., Nikolicheva T.A., Aleshin V.V. Proshloe, nastoyashchee i budushchee zootekhnicheskoi nauki: tr. VIZh., 2004, Vol. 62., No. 3, pp. 69-73 (In Russ.)

9. Ushakova N.A., Nekrasov R.F., Pravdin V.G. i dr. Fundamental’nye issledovaniya, 2012, No. 1, pp. 184-192 (In Russ.)

10. Ushkalova E.A. Farmateka, 2007, No. 6, pp. 18-25 (In Russ.)

11. Ibrahem M.D. Evolution of probiotics in aquatic world: potential effects, the current status in Egypt and recent prospective. J. Adv. Res, 2015, No. 6(6), pp. 765-791.

12. Didenko E.A., Nozdrin G.A. Aktual’nye problemy agropromyshlennogo kompleksa (Actual problems of the agro-industrial complex), Abstracts of papers, 2016, pp. 327-329. (In Russ.)

13. Nozdrin G.A., Tishkov S.N., Ivanova A.B., Nozdrin A.G. Materialy II mezhd. kongressa vet. farmakologov i toksikologov, posv. vos’midesyatiletiyu zasluzhennogo deyatelya nauki RF V.D. Sokolova (Mat. II int. Congress vet. Pharmacologists, & toxicologists, dedicated. 80th anniversary of the honored scientist of the Russian Federation V.D. Sokolov), Abstracts of papers, 2012, pp. 191-192. (In Russ.)

14. Gómez-Gallego C., Junnila J., Mannikko S. et al. A canine-specific probiotic product in treating acute or intermittent diarrhea in dogs: A double-blind placebo-controlled efficacy study. Vet. Microbiol., 2016, No. 197, pp. 122-128.

15. Karkishchenko N.N., Grachev S.V. Rukovodstvo po laboratornym zhivotnym i al’ternativnym modelyam v biomeditsinskikh tekhnologiyakh (Guidance on laboratory animals and alternative models in biomedical technology), Moscow, 2010, 334 p.