Pharmacological effects of bacterial specimens of apathogenic bacilli origin on leucocyte parameters of cows

The paper explores the effect of heterolytics on the basis of apathogenic bacilli Vetom 1 and Vetom 1.23 when applying by means of different ways on quantitative and qualitative parameters of white blood cells of lactating cows. The researchers arranged 4 experimental groups and a control one. Animals of the 1st and 2nd experimental groups received a microbial specimen Vetom 1 dosed 50 and 12.5 mg / kg of body weight, respectively, once a day during 30 days. Animals of the 3rd and 4th experimental groups received microbial preparation Vetom 1.23 dosed 1.0 and 0.5 µl / kg of body weight, respectively, once a day during 30 days. The cows from the control group didn’t receive the specimens. The experiment resulted in the fact that investigated specimens are physiologic for animal organisms and changes in leukocytes and their fractions occur with the same regularity and within the physiological norm. During application of Vetom 1 and Vetom 1.23 the number of leukocytes, monocytes and granulocytes was increased, and the number of lymphocytes decreased. Upon termination of specimen application, the authors found out higher level of leukocytes, monocytes and granulocytes on the 60th day of research, whereas the number of lymphocytes when using Vetom 1 dosed 50 mg/kg of weight at the level of analogues from the control, and in animals of other experimental groups – decreases. The severity of changes in the studied components depended on the specimen used and the dose of it. Maximum increase in white blood cells, monocytes and granulocytes either in the period of specimen application, and after it was observed during application of Vetom 1 dosed 50 mg/kg. Granulocytic immunity is modulated by application of Vetom 1

1. Panin A. N., Malik N. I. Veterinariya, 2006, No. 7, pp. 3–6. (In Russ.)

2. Antimicrobial resistance, global report on surveillance, Dr.Keiji Fukuda, Publications of the World Health Organization are available on the WHO, 2014, 256 p.

3. Murlenkov N. V. Nauchnye issledovaniya – sel’skohozyajstvennomu proizvodstvu (Scientific Research – Agricultural Production), Proceeding of the International Scientific and Practical Conference, 2008, pp. 170–175. (In Russ.)

4. Nozdrin G.A., Gromova A. V., Lelyak A. I. Research Journal of Pharmaceutical, Biological, and Chemical Sciences, 2016, No. 2 (7), 1983 p.

5. Nozdrin G.A. Sb. nauch. tr. vseros. NII ovcevodstva i kozovodstva (Collection of scientific works of the All-Russian Research Institute of Sheep and Goat), 2005, Vol. 224, 224 p.

6. Nozdrin G.A., Ivanova A. B., Nozdrin A. G. Sib. vestn. s.-h. nauki, 2006, No. 7, 63 p. (In Russ.)

7. Suetnova N. V., Nozdrin G.A., Lelyak A.A. Vestn. Ul’yanov. gos. s.-h. akad., 2014, No. 4 (28), pp. 88–93. (In Russ.)

8. Nozdrin G.A., Didenko E.A., Lelyak A. I., Lelyak A.A., Andreeva Z. V. Journal of Animal and Veterinary Advances, 2015, No. 13–24 (14), pp. 339–406

9. Nozdrin G.A., Moruzi I. V., Pishchenko Ye. V., Ivanova A. B., Nurutdinova S. I., Startseva Ye. A. Indian Journal of Science and Technology, 2015, No. 34 (8), pp. 1–6.

10. Kropachev D. V., Moruzi I. V., Starceva E.A., Nozdrin G.A., Pishchenko E. V., Ivanova A. B. Sib. vestn. s.-h. nauki, 2016, No. 3 (250), pp. 47–54. (In Russ.)