Morphological and physical parameters of Argovit silver   nanoparticles

The authors conduct spectral analysis of silver nanoparticles by means of electronic spectroscopy and small-angle scattering. The research showed the stability of nanoparticles sizes, which is achieved by application of polyvilpyrrolidone, which prevents significant formation of their agglomerates, causing significant changes in therapeutic and physico-chemical characteristics of the substance. Asymmetric form of the electronic spectrum showed slight aggregation of nanoparticles with polymorphic polyhedral structures. The slight width of the line of spectral analysis indicates small range of silver particle sizes. The data obtained on the absorption intensity in the high-frequency and low-frequency areas of the spectrum indicate lower number of particles with a size 1 ± 2 nm, and aggregative forms of  about 50 nm in a concentrated solution. The assessment of the size and shape of silver nanoparticles was carried out by means of  transmission electronic microscopy method. It showed spherical, triangular and polyhedral nanoparticles that could be used as medical drugs (oral or parenteral application)  preventing damages for cells and tissues of animals and humans. The studies conducted  by means of transmission electron microscopy method contributed to highlighting the polymorphism of silver nanoparticles that Argovit specimen contains,, and  their size which  is 67.7 ± 19.4 nm with a ellipticity degree of 1.3 ± 0.3. Dilution of Argovit specimen with 1:10 distilled water causes a reduction in nanoparticles size to 36.0 ± 12.7 nm and their ellipticity to 1.19 ± 0.14. The application of the specimen will be effective in pharmacology, provided that pharmacological and toxicological studies are conducted to assess therapeutic effect and safety.

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